Cases of toxic action; from urethral injection of 12 grains,—Pr. xli./369; from vesical injection,—B.M.J. i./89,373; from rectal injection,—L. ii./89,656; from hypodermic injections—B.M.J. i. 89,382; L. ii./88,715; i./89,274; from internal use, 20 grains accidentally swallowed,—L. i./89,292; 4 grains in child of 4 years,—Th. Gaz. Jan. 1889,26; other cases,—B.M.J. i./89,382; Th. Gaz. June 1888,373. Résumé of poisoning cases; more than ¾ grain should not be injected at once. Opium and morphine useless as antidotes; chloroform or ether inhalation recommended to prevent respiratory tetanus.—B.M.J. i./89,311. Toxic effects counteracted by ammonia.—L. i./88,394; ii./88,715; ii./89,1126. Erosis after hypodermic injection.—Pr. xliii./449. Against indiscriminate use, and formation of cocaine habit.—B.M.J. i./89,973.[32] [Footnote 32: Cases of danger from cocaine have generally occurred from its quick absorption in hypodermic use, especially in dental operations. Those who have applied it otherwise most freely recognise little danger. In a large experience of the drug, I have not met with a case in which the so-called “Cocaine habit” has been formed.] Best antidote is amyl nitrite.—B.M.J. i./88,757. Pleurisy relieved by local hypodermic injection of ⅕ to ¼ grain.—B.M.J. ii./88,76. In diabetes, after codeine treatment, cocaine, ¼ grain doses given; overcame obstinate constipation, and ataxic gait disappeared.—L. ii./89,735. Pruritus, several cases relieved by cocaine 2 per cent. in oil of theobroma.—B.M.J. ii./89,194. A successful anæsthetic in skin-grafting; the vitality of tissue is unaffected by its use.—B.M.J. ii./90,113; Pr. xlv. 295. The morning sickness following hypodermic injections of morphine is prevented by combining ½ grain cocaine with the morphine solution.—B.M.J. i./90,1367. Useful in psoriasis of tongue, used before a meal averts pain from passage of food; in painful affections of stomach, affords relief and averts vomiting, as that of pregnancy; in pruritus ani and itching skin diseases; and as an anal injection checks diarrhœa and straining of dysentery.—Ringer’s “Therapeutics,” 12th Edition. Cocaine adopted to relieve morphine craving led to extreme cocaine abuse.—L. ii./90,424. The addition of phenol to hypodermic solution, 1 part to 30, preserves the solution, increases anæsthetic action, and diminishes risk of toxic symptoms following its use. B.M.J. ii./90,94. Resorcin prevents cocaine poisoning; value of both drugs enhanced by combination.—B.M.J. ii./90,506. A 2 per cent. solution recommended in preference to stronger, as it appears to be more quickly absorbed. An overdose usually causes quick pulse, rise of temperature, dilatation of pupil, anorexia, and insomnia. This last yields best to chloral, but requires large doses.—L. ii./91,663. Successful case of laparotomy under cocaine; 12 minims of 20 per cent. solution used.—B. M. J. ii./90, 1022.