Amputation of wrist under cocaine; no shock.—B. M. J., Supp. i./91,202. Cystitis arising from cantharides blistering not prevented by camphor; intolerable pain, unalleviated by morphine, attended fresh blistering, but ceased instantly on the introduction into the prostatic urethra of 15 minims of 1 per cent. solution of cocaine hydrochlorate. The pain recurred in three and a half hours, but yielded at once to ten minims of the solution, and did not return.—L. ii./91,1351. Cocaine decidedly useful in sea-sickness. In crossing Channel two ladies, usually ill, were kept free from the horrid feeling, one by taking six and the other three, ⅒ grain doses.—Mrs. Fenwick-Miller, in Ladies’ Column, _Illustrated London News_, August 27, 1891. _Printed at 74-76, Great Queen Street, London, W.C._