The secondary form of the disease usually occurs in connection with other diseases such as influenza, tuberculosis and acute pharyngitis, or as a result of wound infection. Unhygienic conditions, as unsanitary and poorly ventilated stables and filthy drinking places, play a very important part in the production of the simple or acute form of meningitis. Sudden changes in the feed and the feeding of rotten, mouldy feeds may cause it. In the fall and winter it may follow the feeding of too heavy a ration of shredded fodder or any other dry feed. Other exciting causes are overexertion, changes in climate, excitement, injuries to the head and the feeding of too heavy and concentrated a ration. _The symptoms_ vary in the different individuals, but in general they are the same. At first the animal is dull, or extremely nervous and sensitive to sounds. The pupils of the eye are unevenly contracted at first, later dilated. The eyes may appear staring, or they are rolled about, so that the white portion is prominent. The unusual excitement is manifested in different ways by the different species. During the dull period the animal is indifferent to its surroundings. When it is excited, the pulse beats and respirations are accelerated. The body temperature is often elevated early in the disease. There is a partial or complete loss of appetite. Paralysis may be the most prominent symptom. The animal lies in a natural position, or stretched out and lifting the head occasionally and moving the limbs, but it is unable to rise. Loss of sensibility may gradually progress until the animal becomes semiconscious, or comatose. In case the inflammation is acute and involves the greater portion of the brain and its coverings, death occurs within a few days. Occasionally the animal survives several weeks. There are few permanent or complete recoveries. _The principal lines of treatment_ are preventive measures and careful nursing. This is one of the diseases that can be largely prevented by observing all possible sanitary precautions in caring for animals. It is admitted by writers that the greater majority of cases of inflammation of the brain and its coverings are caused by infection. Proper stable construction, ventilation and disposal of the manure, an occasional disinfection of the stable, cleaning and disinfecting the drinking places and water tanks, and the necessary attention to the ration greatly reduce the loss from this disease.