So it is _assumed_ that when small-pox occurs mildly in the vaccinated—that the disease is modified thereby. The fact being that it depends on the natural susceptibility of the subject and not on vaccination. This different susceptibility in the attacked was pointed out by Rhazes, an Arabian physician, centuries before vaccination was thought of; but what happens when small-pox occurs in a severe form? Let us see—here is Dr. Russell Reynolds’ System of Medicine, and in it, vol. 1, 2nd edition, page 229, is an article by Mr. Marson on small-pox. He tells us that 104 cases of the severe (corymbose) form of small-pox were admitted into the hospital—of these 29 were unvaccinated, 74 were found vaccinated (mark the greater number were vaccinated as usual)—of the 29 unvaccinated, 13 died; of the 74 vaccinated, 32 died;—shewing a difference in the mortality of less than 3 per cent. Of the 104 cases one only had been inoculated, that case died. Here then we see that with all your boasted protection the great majority are found with the mark of the beast on the arm, yet they die at the rate of 42 per cent. Reference had been made to the diminution of small-pox in the parish of St. Giles’s. At a meeting in Kentish Town some months ago, Dr. Ross adduced what he thought to be evidence of the effect of vaccination in St. Giles’s. At that meeting he, Dr. Pearce, had combated Dr. Ross’s argument by shewing that the diminished mortality from small-pox was owing to its absence and its displacement by scarlatina. Dr. Seaton’s statistics had been quoted to-night in proof of the advantage of legislation on the subject. That well paid officer of the Privy Council had drawn up a table for the Epidemiological Society which he, Dr. Pearce, had republished in his essay, and which he begged now to hand to Dr. Routh and Dr. Thomson for their inspection. _Table_, _showing the annual mortality from small-pox in England in three periods_: (1) _Before the enactment of any vaccination laws_; (2) _After vaccination was provided gratuitously_, _but was not obligatory_; _and_ (3) _since vaccination has been obligatory_:—{15} DIVISION 1. DIVISION 2. DIVISION 3.