A determination of even the approximate percentage of degenerate offspring resulting from marriages of consanguinity by direct inquiry is exceedingly difficult. The average human mind is so constituted as to exaggerate unconsciously the unusual in its experience. Herein lies the fallacy in the work of Dr. Bemiss. His material was "furnished exclusively by reputable _physicians_ in various states," and of the 3942 children of consanguineous marriages in the cases thus furnished him, 1134 or 28.8 per cent were in some way "defective." Of these, 145 were deaf and dumb, 85 blind, 308 idiotic, 38 insane, 60 epileptic, 300 scrofulous and 98 deformed. It is evident that a physician in reporting such data to a physician would naturally give cases in which something pathological existed. Even if there were no conscious bias, such cases would be the ones with which a physician would be most likely to come in contact. Dr. Bemiss himself recognized the possibility of this bias. To quote him: It is, natural for contributors to overlook many of the more fortunate results of family intermarriage, and furnish those followed by defective offspring and sterility. The mere existence of either of these conditions would prompt inquiry, while the favorable cases might pass unnoticed. Contributors have been particularly requested to furnish without prejudice or selection all instances of the marriage of consanguinity within their various circles of observation, whatever their results.[51] [Footnote 51: Bemiss. see _Trans. of Am. Med. Asso._, vol. xi, 1858, p. 323.] Yet he does not seem to believe that this bias seriously affects his conclusions. In order as far as possible to avoid this bias, I sent my own circulars to genealogists and others who would naturally be more interested in the relationships than in pathological conditions. I asked, however, that all such results be noted. Among 722 children of first cousins I found 95 or 13 per cent who were defective in the sense in which Bemiss used the term. This is much nearer the actual percentage, but I have reason to believe, as will be seen hereafter, that even this percentage is far too high. A good illustration of the unconscious bias, which I tried to avoid is afforded by the reports on the cause of death among children of first cousins. Only 58 replies were given to this question, and of the 58 deaths 14 or one-fourth were either accidental or otherwise violent, while only one person was reported to have succumbed to pneumonia.