Although this work was begun over twenty years ago, and then yielded negative results, it was only within the last decade that I resumed it more systematically, and under the tutelage of Brown-Séquard himself. During the last two years, however, the experiments have been so much interrupted by illness that even now the research is far from complete. Therefore I will here confine myself to a tabular statement of the results as far as they have hitherto gone, on the understanding that, in so far as they are negative or doubtful, I am not yet prepared to announce them as final. We may take Brown-Séquard's propositions in his own order, as already given on page 104. 1st. Appearance of epilepsy in animals born of parents which had been rendered epileptic by an injury to the spinal cord. 2nd. Appearance of epilepsy also in animals born of parents which had been rendered epileptic by section of the sciatic nerve. I did not repeat these experiments with a view to producing epilepsy, because, as above stated, they had been already and sufficiently corroborated in this respect. But I repeated many times the experiments of dividing the sciatic nerve for the purpose of testing the statements made later on in paragraphs 7 and 8, and observed that it almost always had the effect of producing epilepsy in the animal thus operated upon--and this of a peculiar kind, the chief characteristics of which may here be summarized. The epileptiform habit does not supervene until some considerable time after the operation; it is then transitory, lasting only for some weeks or months. While the habit endures the fits never occur spontaneously, but only as a result of irritating a small area of skin behind the ear on the same side of the body as that on which the sciatic nerve had been divided. Effectual irritation may be either mechanical (such as gentle pinching), electrical, or, though less certainly, thermal. The area of skin in question, soon after the epileptiform habit supervenes, and during all the time that it lasts, swarms with lice of the kind which infest guinea-pigs--i.e. the lice congregate in this area, on account, I think, of the animal being there insensitive, and therefore not disturbing its parasites in that particular spot; otherwise it would presumably throw itself into fits by scratching that spot. On removing the skin from the area in question, no kind or degree of irritation supplied to the subjacent tissue has any effect in producing a fit. A fit never lasts for more than a very few minutes, during which the animal is unconscious and convulsed, though not with any great violence. The epileptiform habit is but rarely transmitted to progeny. Most of these observations are in accordance with those previously made by Brown-Séquard, and also by others who have repeated his experiments under this heading. I can have no doubt that the injury of the sciatic nerve or spinal cord produces a change in some