of the cerebral centres, and that it is this change--whatever it is and in whatever part of the brain it takes place--which causes the remarkable phenomena in question. 3rd. A change in the shape of the ear in animals born of parents in which such a change was the effect of a division of the cervical sympathetic nerve. 4th. Partial closure of the eyelids in animals born of parents in which that state of the eyelids had been caused either by section of the cervical sympathetic nerve, or the removal of the superior cervical ganglion. I have not succeeded in corroborating these results. It must be added, however, that up to the time of going to press my experiments on this, the easiest branch of the research, have been too few fairly to prove a negative. 5th. Exophthalmia in animals born of parents in which an injury to the restiform body had produced that protrusion of the eyeball.... In these animals, modified by heredity, the two eyes generally protruded, although in the parents usually only one showed exophthalmia, the lesion having been made in most cases only on one of the corpora restiformia. I have fully corroborated the statement that injury to a particular spot of the restiform body is quickly followed by a marked protrusion of the eyeball on the same side. I have also had many cases in which some of the progeny of parents thus affected have shown considerable protrusion of the eyeballs on both sides, and this seemingly abnormal protrusion has been occasionally transmitted to the next generation. Nevertheless, I am far from satisfied that this latter fact is anything more than an accidental coincidence. For I have never seen the so-called exophthalmia of progeny exhibited in so high a degree as it occurs in the parents as an immediate result of the operation, while, on examining any large stock of normal guinea-pigs, there is found a considerable amount of individual variation in regard to prominence of eyeballs. Therefore, while not denying that the obviously abnormal amount of protrusion due to the operation may be inherited in lesser degrees, and thus may be the cause of the unusual degree of prominence which is sometimes seen in the eyeballs of progeny born of exophthalmic parents, I am unable to affirm so important a conclusion on the basis supplied by these experiments. 6th. Haematoma and dry gangrene of the ears in animals born of parents in which these ear-alterations had been caused by an injury to the restiform body.