This induced immunity from further attacks has received in the
hands of Metschnikoff a curious and very interesting explanation.
He has shown that an army of small cells, called phagocytes, which
wander through the blood and tissues, are able to attack the
microbes of disease, and that after a struggle they are able in
many cases to kill these voracious invaders. In so doing, however,
the weaker phagocytes succumb to the struggle, while those which
are left alive within the body of the convalescent patient possess
the power of resisting and destroying the particular microbe which
had undertaken the invasion. These resisting phagocytes, selected
from the rest, together with their descendants, who share their
resisting qualities, are able to prevent fresh inroads of the same
enemy. We need not, therefore, assume that this acquired immunity,
the sole relic of the attack, indicates any change in the ordinary
muscle or brain cells of the body, or that the reproductive cells
are in any way altered, for the immunity is due only to a change
in the phagocytic army.
The germ cells in almost every case get off scot-free, and there is
nothing in the organisation of a child to indicate whether or not
his father or mother suffered from measles, or scarlet fever. It
might at first sight be urged, in opposition to this fact, that,
although we cannot recognise the child of a man who suffered from
measles or scarlet fever by any visible sign, yet the child is in
some way different, inasmuch as he is to some extent immune to those
diseases. In favour of this belief, the many instances in which a
fever has been brought to a country never before accessible to the
germ (for instance, the introduction of measles and small-pox to
newly discovered America, where fearful ravages were caused thereby),
may be brought up as evidence to prove that those habitually living
among the germs must have become immune and have transmitted this
immunity to their progeny. Again, the black population of Sierra
Leone have only a mortality of 24 per cent. from malaria, while the
mortality of the white settlers is 47 per cent.;[12] and, in this
case, it may be urged that the black race has become by transmission
of immunity partially immune. But these cases which appear to be
examples of transmitted immunity may receive another, and a much
more simple, explanation. No two children of the same parents are
alike in colour of hair, shape of limb, temperament, etc., and
they also differ widely in their capacity to receive and combat
infection. An epidemic of fever, therefore, will always select to
kill those organically most liable to fall a prey to it, while the
remnant, having by nature greater power of resistance, not only
survive, but may also be calculated upon to produce progeny, on
the whole, as resistant as they are themselves.
_Man has been selected by the Action of the Microbes of Fever._
Public-domain text, read in full here on John Shaqi.
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