In 1849 he resigned his pastorate, and henceforth, with singleness of purpose, devoted himself to his one calling. From time to time new buildings were added to meet new needs. In 1852 an insane asylum for Protestant women was founded, as sisters were often called upon to nurse patients of this class. The building set apart for the purpose was formerly used as military barracks and was given to Fliedner by King Frederick William IV. In 1881 this, as with so many others of the original buildings at Kaiserswerth, became too small for the increase in numbers, and a new building took its place. It stands on an eminence just outside of the village, and is provided with every modern appliance. Fliedner's practical good sense and administrative ability led him to care for all the minor details that were needed for the success of so great an undertaking. He added a dispensary to the hospital, where a sister who had passed a regular examination before the government medical board made up the medicines required for the hospital. Many deaconesses have been trained to the same knowledge, which has been an especially valuable acquisition in the hospitals situated in Eastern countries. Little by little he secured land for farming operations, until there were one hundred and eighty acres in garden and meadow land, generally lying close about the various buildings, and affording means of recreation as well to the inmates. Nearly all of the vegetable and dairy products that are needed are so provided. A bakery, bath-houses, homes for laborers and officials, were added, and bakers, shoemakers, carpenters, and blacksmiths formed part of the staff of the great establishment.