admittedly exerts an influence over bone growth, most markedly (but abnormally) exhibited in acromegaly (excessive bone growth). In this contest for existence in the degenerate types, degeneracy will, of necessity, take the direction of least resistance. As the brain is the last acquirement in vertebrates, considered from the standpoint of necessity, while the face (also a late acquirement) is much less complex, the last, obviously, will present the derangements from degeneration in shape, while the former will show these in shape and function. Furthermore, during the embryonic period the development of the brain will, of necessity, be more immediately affected by degeneracy than the face, which will gain in evolution at its expense. The stigmata of degeneracy, therefore, most likely to attract attention are in the order given, those of the face, jaws, and teeth; ear, eye, cranium; body, bodily functions; brain and spinal cord. Under these last are to be included their mental and nervous functions. The following table summarizes in practical form these stigmata[65]:-- { { Crime. { Ethical { Prostitution and Sexual Degeneracy. { Degeneracy. { Moral Insanity, Pauperism, and Inebriety. { { { Paranoia. { { Adolescent Insanity. { { Periodical Insanity. Cerebral. { Intellectual { Hysteria. { Degeneracy. { Epilepsy. { { Neuroses. { { One-sided Genius. { { Idiocy. { { Sensory { Deaf-Mutism. { Degeneracy. { Congenital Colour Blindness. { { Smell Abnormalities. Spinal Various congenital and hereditary disorders { Exophthalmic Goître. { Lymphoid Degeneracy. { Acromegaly. { Tissue Instability. { Adenoids. { Myxoedema. Nutritive { Plural Births. Degeneracy { Bleeders. { Cancer. { Excessive Fecundity. { Gout. { Early Lipomatosis. { Jaws. { Cleft Palate. { Teeth. { Primitive Uteri. Local { Cloacal conditions (and allied male states) Reversionary { Horseshoe Kidney and allied states. Tendencies. { Cyclopian Monstrosities. { Amelia and Polymelia, Club feet, &c. { Plural mammæ. { Simian muscular and bony states. { Liver and other organ reversions. The factors producing degeneration act by causing nervous exhaustion in the first generation. This implies a practical degeneration in function since tone is lost.