The influence of these disorders in the parent may result in the bony mal-development shown to occur in animals by Charrin and Gley, and in man by Coolidge. The facial bones, jaw, and teeth are peculiarly liable to be thus affected. Though the effect of the disease on the parent be but temporary, the child's development may be checked as to higher tendencies. Thus mothers have borne moral imbeciles, epileptics or lunatics, after a pregnancy during which they were attacked by contagious disease, albeit the children of subsequent and previous pregnancies were normal. The children of pregnancies previous to the one complicated by the contagious disease may be healthy, while those of subsequent pregnancies are defective. Any contagious or infectious disease may not only interfere temporarily with the bodily strength, but may produce complete change in the parent's system extending even to the highest acquirement of man. In some occur changes thus graphically described by Bulwer: "There have been men who, after an illness in which life itself seemed suspended, have arisen as out of a sleep with characters wholly changed. Before gentle, good, and truthful, they now become bitter, malignant, and false. To those whom they before loved they evince repugnance and loathing. Sometimes this change is so marked and irrational that their kindred ascribe it to madness. Not the madness which affects them in the ordinary business of life, but that which turns into harshness and discord the moral harmony which results from natures whole and complete."