The nerve centres controlling nutrition, growth, repair, secretion, and excretion are often as deeply affected as those checks constituting morality. At the periods of physiologic stress these effects are especially noticeable. Moral insanity, intellectual insanity, unequal mental balance, hysteria, precocious sexuality, unconscious mendacity, mental parasitism (the germ of pauperism), epilepsy, neuroses, and all types of nutritive and constitutional defects result. The nutritional defects may appear chiefly in the walls of the blood vessels and lymphatics. While these are most common in the chronic infections and contagions, they often occur in acute typhoid fever, scarlatina, diphtheria, whooping-cough, &c. Proper blood supply and utilisation of waste is thus prevented. Organs cannot perform their function, and are predisposed to disease from disuse and from weakness of the disease-fighting phagocytes and antitoxins. From this results irregularity of organ function, which is hereditarily transmissible. The weakened vessel walls yield to strain, and thus produce local stomach, bowel, liver, gland, and kidney disorders. This organ weakness may alone be transmitted to the offspring. The functions of the great glands (thyroid, thymus, suprarenals, pituitary body, bone-marrow, testicles and ovaries) which secrete principles necessary to the equal balance of nutrition are perverted. The liver, in the acute but more particularly the chronic contagions, paralysed in nerve tone, fails in its function of poison-destroyer, as for the same reason the kidneys fail in their power of ejecting hurtful waste. Through this interaction of perverted nutrition, imperfect poison-destruction, and deficient waste ejection result and continue the states of nervous exhaustion after the contagions and infections. Thus nerve exhaustion with its suspicion, its capricious hopefulness and gaiety, is practically continuous in tuberculosis, syphilis, and leprosy.