The more chronic changes of this organ, be they moderate or of a grade to which one must apply the term fibrosis, are rather uncommon when one considers the number of animals with prolonged infection, anemia, skeletal diseases and hepatic cirrhoses; these are the conditions that take a prominent place in the associated pathology and history. There is no essential difference in the organ throughout the animal kingdom, and one may find as far down as the struthious birds analogies to the processes of domestic and human animals. SPECIAL SUBJECTS—AMYLOID. Amyloid changes in the spleen have occurred in the following orders: Primates, Carnivora, Rodentia, Marsupialia, Passeres, Galli, Gaviæ, and Anseres, fourteen cases in all. This infiltration is usually ascribed to long continued suppuration or chronic infection, every one admitting, however, that once in a great while a case is seen wherein no cause can be discovered. In this laboratory we have a high percentage of cases without adequate accompanying pathology so that we have called six of the above cases primary or idiopathic. The gross appearance of the spleen is in all these cases that of an enlarged, firm, homogeneous body without the sago spots usually described for this change. Microscopically the infiltration occurs first in the vessel walls, thence spreading to the sinus walls and reticulum. Joest in discussing this infiltration[19], states that it is comparatively rare among the domestic animals, where it may appear under the usual conditions or as a primary affection; it seems at times to follow unsuitable feeding. According to this author, the “sago” type is more common than the “bacony;” this has not been our experience. The most conspicuous example is given here. European Badger (_Meles meles_) Adult ♀ . Gradual failure for two weeks. DIAGNOSIS.—Amyloidosis. Chronic parenchymatous nephritis. Emphysema of lungs.