Muscles atrophic; fat scanty. Heart is dilated and muscle is red- brown. Aorta is jaundiced and there is a small patch of atheroma near the anterior leaflet of aortic valve and about 5 mm. above it. Abdomen contains a slight amount of clear fluid, no adhesions. Liver is normal in size, smooth surface, sharp edges, firm consistency, yellow color. The section surface is glistening, smooth and moist. The spleen is very hard, greatly enlarged (25 × 6 × 2 cm.) and lies across the abdomen over the intestines. It is pale red and very bacony. In iodin the tissue stains a mahogany brown. The kidney is normal in size. (5½ x 3 cm.). The capsule is smooth and strips easily leaving a smooth, yellow surface. Organ is firm. The section surface is glistening, has a relatively narrowed cortex and relatively wide medulla. The glomeruli are barely visible but stain a mahogany brown in iodin. The adrenals are 12 × 10 × 4 mm. The cortex is wide, dull yellow and regular. The zone beneath fades into the cortex although rather abruptly. The centre of both glands is occupied by an irregular pale yellow, sharply outlined nodule suggestive of solid medulla, tubercle or tumor. The zone between cortex and this is gray, irregular and firm. This is practically a normal figuration. The stomach is empty, mucosa apparently normal. Intestines were not opened but serosa seems normal; when opened after Kaiserling fixation they seem normal. The pancreas is normal in size, firm and pale. Lymphatics of the mesentery are slightly enlarged, soft, homogeneous pale yellow. HISTOLOGICAL NOTES.—Lung seems somewhat atrophic and there are some vesicular ruptures. One small patch of amyloid found in blood vessel wall. Liver shows slight capillary congestion and granularity of parenchyma. There is a marked blood vessel amyloid deposit not only in interlobular spaces but in intralobular capillaries. Spleen, no trace of splenic tissue recognizable in section. It is composed of more or less eosin-staining material surrounding single, or small collections of round or plasma cells. Kidney shows marked amyloidosis of glomeruli and slight deposit in blood vessel walls and in the increased connective tissue. There is a general moderate fibrosis; irregular tubules; low epithelium and hyaline casts. Heart muscle fibres are small and stain deeply. No amyloid in section. No pigmentation although section is suggestive of brown atrophy. Adrenal is practically negative. There seems to be slightly more connective tissue than normal but parenchyma may be considered normal. At one place in the cortex there are some structures of deep layer included in vesicular layer. This seems like a structural malformation. NECROSES.