The fibroses of the liver are not infrequently associated with some enlargement of the organ under discussion. At this laboratory hepatic cirrhoses are divided into Portal, Biliary, Fatty, Perilobular and Vascular. By a study of the spleens in these cases a few facts have been obtained. In mammalian portal cirrhoses there is usually a very moderate but definite increase in the size of the spleen due to connective tissue increase in the trabeculæ and reticulum, with very small compact follicles. Among the birds the organ seldom shows more that a moderate congestion and diffuse hyperplasia. In the mammalian biliary cirrhoses there is almost without exception a definite enlargement due to fibrosis and follicular hyperplasia. Among the birds the process is very far from uniform, there being just as often no change, as a congestion and hyperplasia, or as a mild fibrosis; it is notable, however, that pigmentation is commonly met in this class. No noteworthy change is met with in the spleen of fatty hepatic cirrhoses. We have no record of cyanotic induration of the spleen accompanying a similar condition in the liver. When the condition of perilobular hepatic fibrosis has been met a distinct increase of the splenic pigment is usually found. In reviewing the facts in this paragraph one is forced to the conclusion that, with the exception of the frank infective cases, there is no definite relation of the splenic changes to those in hepatic cirrhosis, a fact made perhaps the more significant in view of the idea held in some quarters that the primary change in this pathological process occurs in the spleen. PERISPLENITIS. Perisplenitis of an acute or fibrosing variety as a part of peritonitis or as the result of an injury to the splenic region, has been encountered on numerous occasions and offers nothing worthy of comment, but the so-called “sugar-icing” spleen, associated with perihepatitis and general peritoneal thickening, and with an obscure relation to tuberculosis has not been seen. As we shall learn later peritoneal or massive intestinal tuberculosis is not common in the lower animals. A diffuse fibrous thickening of a pearl gray glistening appearance, has occurred in five monkeys harboring the Filaria gracilis in the peritoneum. TUBERCULOSIS.