(8) Animal parasites have long been considered as one of the causes of gastrointestinal inflammation, a condition largely due to copying from book to book of a few facts and more impressions. The sum of reliable information to-day would seem to indicate that a few parasites—uncinaria being the most conspicuous example of this type—draw considerable blood from the mucosa, that a few, like uncinaria and dibothriocephalus, elaborate an absorbable toxin, that some, notably ascarids, produce an irritating substance, and that many possess the power in themselves or by some excretion to act as antiferments. These factors, were they all combined in one worm, might probably irritate the mucosa sufficiently to produce inflammation, but it is not easy to imagine that they would cause an acute specific condition. It is much more easily conceived that with tiny hemorrhages or ulcerations of mucosæ, bacteria might get in their work or if considerable ferment were neutralized, maldigestion, flatulence or indigestive irritation would ensue. With certain worms like esophagostomum there is considerable evidence to show that a chronic fibrous disease of the intestinal wall arises, but in this case the parasite resides in the mucosa and acts as a foreign body. It would seem, however, that the most important influence that animal parasites exert is to be found in the preparation of the mucosa for the action of bacteria. Masses of parasites may of course physically obstruct the lumen and lead to intestinal stasis and dilatation. INFLAMMATION. In analyzing the cause of a gastroenteritis and its consequent effect upon the wall of the tube and upon the viscera, certain physical, chemical and physiological factors must be considered. Whether this may be directly the effect of bacteria or poisons from worms or some other factor seems of little moment since in any fully developed case, symptoms and effects are comparable. Moreover it seems that pathological anatomy, both gross and minute, is essentially the same from Primates to struthious birds, the highest and lowest of the two classes here considered. By this is meant that the acute congestive condition of the gut tract with solution of the surface, to which we have applied the name of toxic enteritis, seems to be met with in this form throughout all the orders. So too catarrhal inflammations are the same to the naked eye and under the microscope, due allowance being made for the fact that mammals use polynuclear cells for exudative purposes while birds employ mononuclears. Concomitantly with these conditions, a degenerative process may be going on in the liver and kidney, and hyperplasias, especially in the true infective processes, will be found in the related lymphatic structures.