Amyloid deposit is reported with reasonable frequency in domesticated animals, causing in them a fairly definite entity, being as usual related to the effects of long continued or repeated infectious disease. Wild animals suffer from this condition but rarely and therefore to our few cases will be given a short discussion separately. An Indian Paradoxure (_Paradoxurus niger_) had patches of amyloid irregularly distributed through the organ. The animal had a carcinoma of the head of the pancreas, an obstructive biliary cirrhosis in a state of atrophy and a chronic nephritis with arteriosclerosis. There was nothing peculiar about the distribution of the deposit as there was in the next case, a Badger (_Meles meles_) where amyloid was found around the interlobular vessels and extending in the lobules along their canaliculi. This latter case seemed without cause and we have considered it a primary amyloidosis, the spleen, heart muscle, kidneys, intestines and other structures being affected. (See Fig. 7.) A third mammalian case concerned a Dasyure (_Dasyurus viverrinus_) which showed distinct intralobular collections. Its cause was a chronic suppurative process in the jaw bone. Avian livers are somewhat more prone to show amyloid deposits, eight cases being on record. Four occurred in the Passeres, one each in Columbæ and Impennes and two in Anseres. Three were associated with chronic infectious disease and two with well established nematode parasitism. The remaining three, classed as primary, were not related to any other lesions, in two the amyloid liver being the only finding. The next abnormal deposition related to the physiology of the organ is blood pigmentation. Normally hemic pigment is dispensed with very rapidly but under unnatural conditions it accumulates. In only one order is there any noteworthy percentage of hemosiderosis, the carnivores, the remainder showing a very trifling incidence. DEGENERATIONS. Going further into the physicochemical alterations of the liver brings us to consideration of those changes known as degenerations— parenchymatous, fatty, hydropic, hyaline, all of which we shall group under one heading. They occur in a great variety of conditions and do not appear to be specific, nor as the records are analyzed do they appear to occur preëminently in any one disease of the lower animals. The percentages are however higher for orders and families whose diet contains relatively more protein, carnivores, the higher marsupials, accipitrine, and wading birds. ACUTE ATROPHY.