The macroscopic anatomy of hepatitis in birds is peculiar in showing a definite swelling with spots of gray or yellow color, sometimes coalescing to form irregular areas. These are much more definite than in the mammalian organ where swelling and hemorrhage are the commoner findings. These pale spots are of two origins. They may be focal necroses of the hepatic cells, with or without circumferential congestion or hemorrhage to make them stand out. In amœbic, coccidial and typhoid livers such is the type of change. In septicemia and cholera, the mottlings are made up of increased interstitial mononuclear areas, with blood cells and shadow cells numerously present. I have seen what was in all probability a stage of repair after both these kinds of change. In the former, regeneration seemed to take place from adjoining liver cells, there being in the section no evidence of increased bile ducts to make new hepatic cells. It seemed also that phagocytes were derived from blood cells and not from Kupffer’s cells. In the infiltrative lesion disappearance of the liver cells from the groups leaving compressed and deeply granular remnants was all that could be determined. Regeneration seemed to be progressing in the manner just outlined. NECROSES. The degenerative and infiltrative areas of acute hepatitis are simulated by focal necroses in livers not the seat of a general hepatitis from which they can be differentiated only by the microscope. These small areas of local tissue death are quite common in all pathological processes but are most common in the liver, possibly because of its exposure to toxins from the intestine. Their exact origin is not determined, various explanations being given. The somewhat distinct distribution in mammals _versus_ that in birds may help in the final decision. In the former, focal necroses are more often encountered midway in the anatomic lobule and around the central vein whereas a perivascular location seems the usual position in the bird.