Massive necroses of the liver may be of considerable importance in veterinary medicine. They take their origin in several different ways. The commonest in our records are those due to cecal coccidiosis and amœbiasis (quail disease and blackhead) while from the primary seat of these two infectious diseases, the cecum, may originate the virus of nonspecific hepatic necroses. We have observed several birds, passerine, psittacine and gallinaceous, which at autopsy showed a distention of the cloaca, ceca, and lower small intestine with urates and slime but no mural inflammation and a large area of necrosis in the liver. This suggests perhaps a “white diarrhœa” but it did not occur in epizoötics and other morbid anatomy of this specific disease was absent. These frequent instances of association between the colonic area and the liver seem to suggest the transfer of necrotizing organisms, just as amœbæ travel, and to indicate measures to clean out the tract when birds become “plastered.” Massive necroses also arise from mould disease, and from infection with the necrosis bacillus, emanating from nearby infectious foci, or _via_ the normal passageways from the intestine. Massive areas of degeneration may form by the coalescing of numerous foci, in any septicemic disease. ABSCESS. In man, amœbæ, flukes, cestodes and biliary tract infection are the commonest causes of purulent collections within the liver. In the lower mammals parasites play practically a solitary rôle at least as the major influence in localizing the collection, bacteria from the intestine doing the rest. We have one case of massive abscess in a porcupine suffering with septic pneumonia, the suppuration in the liver being due to the colon bacillus, the general septicemia probably being from distemper. Monkeys have shown more abscesses than any other order, three being observed. One was due to infestation with trichocephalus which had apparently penetrated from the colonic wall into the liver through adhesions formed between these two structures. Another seems certainly amœbic but these protozoa could not be found, while the third followed an ulcerative enterocolitis of unknown cause. Two cats were seen with parasitic abscesses; one harbored _Distoma_ or _Clonorchis sinensis_, the other a nematode of ascaris type. The topographic distribution of these six hepatic abscesses was interesting. The position of the abscess is not mentioned in one case but of the remaining five three were entirely in the right lobe, one had the major lesion on the right side and smaller separate abscesses spread over the organ, and one with about equal distribution in all lobes. All three confined to the right side were solitary. Abscesses of considerable size are not met with in the bird as in the mammal perhaps because the former does not form real pus, necroses developing instead.