As an introduction to the strict pathology of the heart it might be well to outline the headings of the scheme upon which it seems desirable to study the subject. It is hardly profitable to take up seriatim the ordinary general pathological processes as discussed in systems of pathology for it is our purpose to show the distribution of basic aberrations from the normal in terms of zoological position. To this end one must consider the response of the heart (a) to damaging influences and (b) to a demand for increased work. In the first group come degenerations and inflammations, upon which may succeed an incompetency in the form of dilatation. The response of the normal heart to any physical demand greater than customary has usually been thought to lie in the direction of hypertrophy, but on occasion it has seemed to be in the form of dilatation, especially if the strain has been sudden and severe. Starling thinks that the primary and normal reaction of the heart to physical strain is always dilatation. The idea of hypertrophy must not be confused with an understanding of the relatively large hearts in animals whose habits demand great cardiac power, for then it is their norm and might be called “physiological cardiac hyperplasia.” I shall use the terms “increased muscle bulk” and “increased chamber space” as preferable to hypertrophy and dilatation; this also focuses attention upon the two features of an enlarged heart. DEGENERATIONS AND INFLAMMATIONS. Degenerative changes in disease are recorded in our system as amyloid, hyaline, fatty metamorphosis, granular and cloudy degeneration. While there is perhaps between some of these conditions and true myocarditis a matter only of degree, the records have been analyzed as filed and perhaps some lessons can be learned from the responses of the various zoological orders. In the accompanying Table 1 will be found the distribution of degenerative and inflammatory lesions through the zoological orders. The percentages speak for themselves but deserve as well some consideration from the standpoint of normal heart value; this will be taken up later after the other lesions have been discussed.