The wasting during later periods of the disease is absolutely characteristic, and different from that of other wasting diseases, such as chronic broncho-pneumonia, tuberculosis, etc. The patients finally become walking skeletons. The red corpuscles of the blood progressively decrease, until the number may fall as low as 800,000 or even 500,000 red corpuscles instead of six millions, the normal figure. The œdema common to wasting conditions appears, and the animals die without suffering, in a condition of absolute exhaustion. [Illustration: $1] Complications are rare, though occasionally intestinal hæmorrhage or broncho-pneumonia occurs. The temperature, which remains normal or shows very slight changes throughout the course of the disease, may then oscillate between 101° and 103° Fahr. (38° and 39·5° C.). [Illustration: $1] =Lesions.= At the first glance no lesions can be detected on post-mortem examination except those of generalised wasting, but when the autopsy is carried out immediately after death all the interior of the intestine appears affected. The mucous membrane of the abomasum and the mucous folds appear infiltrated, thickened, and with moderate sub-epithelial congestion. The intestine seems friable, and tears with the slightest traction. The sub-epithelial portions of the mucous folds are infiltrated and congested, while the more prominent parts of the folds, which are exposed to the friction of semi-digested food, become eroded. Throughout the length of the jejeunum and ileum the mucous membrane exhibits multitudes of small ulcerations. Histologically, the epithelium and the glands seem atrophied, without any inflammatory change having occurred in the mucous or submucous coats. The colon and the cæcum show similar lesions, and in addition brown deposits of pigment under the mucous membrane and along the course of the small blood-vessels. This lesion resembles that found in chronic dysentery in man, and suggested to Moussu a possible connection between the two diseases. The liver is less than the normal size. In the heart Moussu has seen one case of sclerosis of the auricles and calcareous infiltration of the sub-endothelial lining of the aorta. In several instances he has noted calcareous infiltration of the mesenteric lymphatic gland. =Diagnosis.= It is easy to diagnose this condition, and quite possible to distinguish it from the diarrhœa of tuberculous enteritis, infectious hepatitis, and other conditions. =Prognosis.= The prognosis is very grave, and the disease almost always proves fatal. =Treatment.= At the present moment no curative treatment is known. Lignières’ treatment—viz., the injection of physiological salt solution and serum from healthy oxen, and saline solution or defibrinated blood—has never given permanently successful results.