[54] The degree of pressure necessary for producing this effect is proportioned to the susceptibility of the granulations, or organic particles, for receiving the impression of being in contact. When a part is healthy, the mere circumstance of juxtaposition is sufficient for this purpose; and, in a healthy ulcer, the weight of the body applied, such as powdered chalk, or plaster of Paris, or at least the gentle pressure of a stocking, or easy bandage, is all that is necessary. But, when the action is too low, and the granulations are consequently imperfect, both in their structure, power of acting, and capability of receiving impressions, the contact, in order to operate, must be nearer, and more complete; or, in other words, the pressure must be greater. In these cases, bandages not only act on the surface, but also on the parts below, and, therefore, increase the degree of contact of the newly-formed organic particles, and thus strengthen the part. The good effects of pressure, applied in a degree proportioned to the effect which we wish to produce, and to the state of the sore, are so universal, that it is unnecessary to give any examples of its success and utility. But, at the same time, it must be observed, that in old ulcers, and even in many of a more recent date, which have been much neglected, no application whatever will produce an uninterrupted cure; for, after some time, it ceases to produce the same effect upon the action. The part seems, by continuance, to be less acted on by the agent; the action is less affected, and slowly returns to its former state of imperfection. It is therefore necessary, either that we from time to time increase the power of our application, or vary our remedies, whenever the process becomes stationary. The latter is generally the most effectual way; and the remedies which we alternate with the effects of pressure, are those of what have been called the stimulating kind; but which of the individuals of this division ought to be employed, cannot always be determined, because one succeeds better in a particular instance than in another. It would, however, be of much importance, to ascertain which in general operated most effectually; because, if we employ one which does no positive good, we sustain positive harm; for the action is allowed to persevere in a retrograde process. I, therefore, paid particular attention to the operation of these applications, in the patients who were under my care in the Glasgow Infirmary.