Pilcher and Sollmann [Footnote: Pilcher and Sollmann: Jour. Pharmacol. and Exper. Therap., 1913, vi, 323.] have shown that the fall of blood pressure after the administration of nitrites is mostly due to the action of these drugs on the peripheral vessels. Chloroform, of course, depressed the vasomotor center, but ether had no effect on this center, or slightly stimulated it. Such stimulation, however, Pilcher and Sollmann believe may be secondary to asphyxia. Nicotin they found to cause intense stimulation of the vasomotor center. Ergot and hydrastis and its alkaloids seem to have no effect on the vasomotor center. Strophanthus acted on this center only moderately, and digitalis very slightly, if at all. Camphor in doses large enough to cause convulsions stimulated the vasomotor center. In smaller doses it generally stimulated the center moderately, but not always. Even when this center was stimulated, however, the camphor did not necessarily increase the blood pressure. The rise in blood pressure from epinephrin is due entirely to its action on the peripheral blood vessels and the heart. It has no action on the vasomotor center. They found that strychnin in large doses may stimulate the vasomotor center moderately, but usually it did not act on this center unless the patient was asphyxiated; then it acted intensely. The conclusion to be drawn from their experiments is that when there is asphyxia, increased venous pressure, and also a rising blood pressure from the stimulation of carbon dioxid, strychnin is contraindicated. It should be recognized that digitalis very frequently not only does not raise blood pressure, but also may lower it; especially in aortic insufficiency and when there is cyanosis. Even with some forms of angina pectoris, digitalis in small doses may reduce the frequency of the pain. This decrease of pain following the use of digitalis has in some cases been ascribed to the improvement of coronary circulation and resulting better nutrition of heart muscle. Of course under these conditions the action of digitalis must be carefully watched, and it should not be given too long.