Excessive use of alcohol, while tending to promote hypertension by the disturbances that it causes, may give, by causing a weak heart muscle, a permanent low blood pressure. A single large dose of alcohol always lowers the blood pressure. Arteriosclerosis frequently reaches a stage when the blood pressure is low, and with atheroma of the arteries of the arms a true blood pressure is difficult to obtain. Addison's disease, or any other organic lesion of the suprarenals, will lower the pressure, while stimulation of the suprarenals increases the pressure. Any great drain on the system, whether from diabetes without nephritis, or from profuse diarrhea of any type, will cause hypotension. Occasionally a girl with chlorosis who is not menstruating may have an increased blood pressure. Many of the hemorrhagic or purpuric conditions will show a hypotension. Meningitis in various forms may show a hypertension from cerebral and nervous irritation. Neurasthenic patients quite generally have hypotension, although occasionally with suprarenal disturbance they may have an increased tension. In the hypotension of surgical shock and in shock during anesthesia, Henderson's findings [Footnote: Henderson: Am. Jour. Physiol., 1910, xxvii, 158.] that hyperoxygenation and insufficient carbon dioxid may be partially responsible for the condition should be remembered, and it has long been known that carbon dioxid congestion, as caused by laughing gas anesthesia, for instance, increases the blood pressure. A systolic pressure of 110 mm. or lower in an adult should be considered hypotension, anything below 105 mm. calls for treatment, and a systolic pressure of 100 or lower in an adult calls for rest from all active duties. These patients are weary, they have mental and physical tire, may get short breathed, may have palpitation of the heart, and often have headaches and dizziness from imperfect circulation in the head. There may be edemas of the legs and ankles toward night. If such patients have the systolic blood pressure raised even a small amount, or if the diastolic pressure, which is very low, is raised even a small amount, they immediately feel better. If the kidneys are normal, they should have meat as part of their diet. If they are not nervous and irritable, coffee and tea should be allowed, except at the evening meal. While sleep may tend to lower pressure somewhat, these patients' hearts require a long bed rest; in other words, they should go to bed at an early hour. They should rise early, however, in the morning, and, as recommended by Goodman, [Footnote: Goodman: Am. Jour. Med. Sc., April, 1914, p. 503.] they should perform mild calisthenic exercises before dressing.