The writer of these papers, composed at different times for specific occasions, without thought at their writing, of eventual collective publication, was beloved by his friends for qualities of heart and mind that were not associated by them with his professional achievements. Yet as one thinks of him in retrospect, appraising him as a physician, one becomes more and more convinced that his great significance for American medicine sprang from those very qualities which endeared him in his personal relations, applied to and interwoven with his professional life. Intellectual and emotional sanity and integrity, from which wisdom, kindness and courtesy are derived, were the natural endowments which brought him distinction as a human being and which gave him an importance for American medicine possessed by very few of his contemporaries. In the history of medicine there are many names associated with the discovery of facts, with learned treatises and with technical achievements of one kind or another; there are relatively few of whom we think especially as physicians in the sense in which this word is used in regard to Suydenham, for instance. It is a rare blending of learning and humanity, incisiveness of intellect and sensitiveness of the spirit, which occasionally come together in an individual who chooses the calling of Medicine; and then we have the great physician. His professional life fell into a period of reorganization and unparalleled expansion in the medical world in which public attention quite naturally was focused on the material phases of these changes. Fundamental to these, however, and far more permanently significant, there was an intellectual reorganization and expansion which demanded the development of new leaders who might accomplish for our generation what men like Neusser, Nothnagel, McKenzie, Osler, Delafield, Shattuck and James had accomplished for the one just past. Of these young standard-bearers of the new Medicine he had become an affectionately acknowledged leader. As he grew in maturity and authority his interests were forced, almost in spite of himself, beyond his immediate work in laboratory and wards, into the more general problem of the relations of his profession to education, public health, sociology and, we may call it, its moral and philosophical bearing upon community life. In the educational phases of his work, the clinic which he headed at the Boston City Hospital represents a contribution to the constructive coördination of teaching, investigation and the care of the sick which solved many difficult problems and has already exerted a profound and lasting influence upon medical organization. This was his chief work at the end of his life and here he was continuing the studies which had already made him a noteworthy investigator and teacher.