“When given in full doses, cannabis Indica produces a feeling of exhilaration, with a condition of reverie, and a train of mental and nervous phenomena, which varies very much according to the temperament or idiosyncrasies of the subject, and very probably also, to some extent, according to the nature of his surroundings. The sensations are generally spoken of as very pleasurable; often beautiful visions float before the eyes, and a sense of ecstacy fills the whole being; sometimes the venereal appetites are greatly excited; sometimes loud laughter, constant giggling, and other indications of mirth are present. Some years since, in experimenting with the American extract, I took a very large dose, and in the essay upon the subject (_Proceedings of the American Philosophical Society_, 1869, vol. xi. p. 226), the result was described as follows:— “About half-past four P.M., September 23, I took most of the extract. No immediate symptoms were produced. About seven P.M. a professional call was requested, and, forgetting all about the hemp, I went out and saw my patient. While writing the prescription I became perfectly oblivious to surrounding objects, but went on writing, without any check to or deviation from the ordinary series of mental acts connected with the process, at least that I am aware of. When the recipe was finished, I suddenly recollected where I was, and, looking up, saw my patient sitting quietly before me. The conviction was irresistible that I had sat thus many minutes, perhaps hours, and directly the idea fastened itself that the hemp had commenced to act, and had thrown me into a trance-like state of considerable duration, during which I had been stupidly sitting before my wondering patient. I hastily arose and apologized for remaining so long, but was assured I had only been a very few minutes. About seven and a half P.M. I returned home. I was by this time quite excited, and the feeling of hilarity now rapidly increased. It was not a sensuous feeling, in the ordinary meaning of the term; it was not merely an intellectual excitation; it was a sort of _bien-être_—the very opposite to _malaise_. It did not come from without; it was not connected with any passion or sense. It was simply a feeling of inner joyousness; the heart seemed buoyant beyond all trouble; the whole system felt as though all sense of fatigue were forever banished; the mind gladly ran riot, free constantly to leap from one idea to another, apparently unbound from its ordinary laws. I was disposed to laugh; to make comic gestures; one very frequently recurrent fancy was to imitate with the arms the motions of a fiddler, and with the lips the tune he was supposed to be playing. There was nothing like wild delirium, nor any hallucinations that I remember. At no time had I any visions, or at least any that I can now call to mind; but a person who was with me at that time states that once I raised my