December 22. Patient was very restless in the night; got out of bed, ran about, laid down again, perspired freely, asked for morphia. The abundant perspiration lasted till midday and was accompanied by determination of blood to the head. Patient suffered from giddiness and felt greatly tired. Appetite poor. Frequent retching, but no vomiting. December 23. Patient has slept little. Three relaxed motions in the morning. Symptoms the same as on the previous day. New symptoms: twitchings in the extremities, excitement, sensitiveness to the light, and epigastric pains. To remove the latter symptom sinapisms to the stomach, hot poultices and cupping (four times) were attended with success. Frequent vomiting. December 24. Patient has only slept for a few hours. A great deal of sneezing; eight relaxed motions. In the course of the day he felt well. December 25. The pains and pressure in the region of the stomach have returned and he had also palpitation of the heart, was very much exhausted and suffered from tenesmus. Two seminal emissions. December 26. Four relaxed motions, shivering, feels uncomfortable. December 28. Patient has only had two hours’ rest. Hands and feet burning hot. Eight motions; during the day he felt weak, complains of formication in the hands and feet. December 29. Uncomfortable feeling continuing the whole of the day. Patient’s face was of a dark red hue; he complained of hyperæsthesia in the feet and of cold. While reading a letter from his wife he began to cry, although the contents showed no reason for his doing so. Appetite good. Two relaxed motions. December 30. Slept from 3 to 7 A.M. Two relaxed motions. A great deal of sneezing, pressure in the epigastrium, appetite small. January 3, 1876. Slept from 12 to 4 A.M., after running about in a restless manner. Formication in hands and feet. January 6. General condition satisfactory. Appetite increased. January 14. The patient has continued to recover his strength. Bodily functions normal. Sexual power has returned. _Urine._—During the first weeks of abstinence from morphia the urine contained albumen. Patient left the Institution on January 22, in perfect health. He has not had a relapse. Neuralgia of one-half of the face, in all respects like malarial hemicrania, I have seen in two cases. In neither were there other symptoms of malarial trouble. Both cases yielded to quinine and arsenic. Super-sensitiveness of the skin, sometimes of the whole body, more often of a limb, or a feeling of numbness, is not uncommon. A fact that I had noticed before I commenced the special study of this subject is, that those opium eaters who live past middle age usually die from paralysis. In four instances I have seen this. In all four cases the persons took laudanum. CHAPTER V. ACCIDENTS INCIDENT TO THE SUBCUTANEOUS INJECTION OF MORPHIA.