1. Lady, fifty-eight; spare but muscular, and of more than ordinary intelligence and strength of will. Took morphine for some time, to overcome sleeplessness due to painful affection of the bladder. Six months before Dr. M. saw her she had been taking chloral, twenty grains at night, to commence, finally one hundred and fifty grains in the twenty-four hours. At his first visit found her almost a skeleton, hard to rouse, maudlin and semi-narcotized. When questioned, answered wildly and disjointedly. State of mind closely bordering on imbecility. Pupils dilated. Pulse slow, feeble and intermittent. Face flushed and anxious. This had been her condition for many weeks. Her rare lucid intervals were spent in childish whining for more chloral, or in cunning attempts to deceive her attendants and obtain an extra dose surreptitiously. From having been a cheerful, upright, exceptionally intelligent and strong-willed woman, she had become morose, deceitful, and imbecile alike in intellect, memory and will. Points of exceptional interest. 1. Marked decubitus, with not mere indisposition, but, at times, manifest incapacity for exertion. 2. Dark, erythematous flush over head and neck, with extraordinary twitching of facial muscles. 3. Partial paralysis of the œsophagus, not spasmodic stricture; but sluggish and incomplete contraction of the muscles of deglutition, with regard to both food and drink. This was well marked in Case 2, and in both recurred at intervals for many months; even after convalescence was established. 4. Dimness of sight; eyes bloodshot and constantly watering. Once, after total cessation of chloral, temporary loss of vision, lasting, with intervals, two days. 5. Dryness of the hair. CASE 2.—Lady, aged forty-five, good health and keen intellect. Insomnia from worry and from dyspepsia. Had taken chloral for two years. At first only at bedtime; after a time during the day also. Never above seventy grains in twenty-four hours. Both physical and mental exhaustion, morbid fear, confusion of mind, lack of concentration and impairment of memory. (She was, however, an authoress, apparently doing her regular literary work.—K.) POINTS OF INTEREST. 1. Erythema of head and neck. 2. Excessive hyperæmia after smallest quantity of wine or beer. 3. Partial paralysis of the œsophagus, with nervous disinclination to take food or drink. 4. Dimness of sight, with eyes bloodshot and overflowing with tears. Marked projection of eyeballs. 5. Intense nausea, oftentimes, after taking chloral.