Dr. James Bunting[63] had a patient who took large doses of chloral daily, with the effect of perverting the morals and producing a tendency to suicide. Dr. Thos. Bond[64] relates the case of a friend, a young medical man, who died of acute mania, produced by continued and excessive use of chloral. The memory, especially for words, is greatly impaired. I have seen one case of this kind, and one such was reported to me by a medical gentleman in Boston, who forgot to sign his name to his very interesting letter. The patient whom I saw not only had an impaired memory for words, but would use one word for another, as “slippers” for “hat,” or “pen” for “coat.” He had been using the drug for nearly six years, and, although profoundly affected by it, would, at times, be decidedly better than at others. Dr. G. W. Davis, of Chico, California, writes me of the case of a lady who had been using the drug for some time. She first took it for facial neuralgia. She takes from forty to sixty grains daily. Her present health is fair. “She complains, however, of a fullness about the head, confusion of ideas, and loss of memory.” Drs. Norton Folsom, of Boston, and J. W. Parsons,[65] of Portsmouth, N. H., relate cases where the habitual use of this drug produced childishness, fretfulness, muscular tremor, and, in Dr. Parsons’ case, seemed to aggravate an existing attack of melancholia. Dr. James Perrigo,[65] of Montreal, relates the case of an old lady, sixty years of age, who took chloral, forty-five grains at bedtime, and fifteen grains during the day. She was partially insane, but whether from the chloral or not, I have been unable to learn. Maudsley[65] uses it but rarely in insanity. “Sometimes in melancholia. Rarely in mania, and then only when subacute.” Similar testimony was obtained from Drs. Maudsley, Clouston and Lindsay, by the Committee of the London Clinical Society. Dr. A. P. Hayne, Medical Superintendent Inebriate Asylum, San Francisco, Cal., writes me: “There is no doubt but that its long continued use is one of the causes of insanity. I think I may safely say that several cases of this kind have fallen under my immediate observation, where chloral has been the remote or immediate cause of the disease.” Dr. H. H. Doane,[66] of Litchfield, Ohio, reports a case where chloral produced, in an habituè, melancholia, with suicidal tendency. The following interesting case history was sent me by Dr. Frank R. Fry, of St. Louis, Mo.:—