“Patient’s age, twenty-four years. Had been surrounded by a set of vicious companions, and got to drinking excessively. Had an attack of delirium tremens, for which chloral, bromide of potassium and valerian had each been prescribed. In a fit of virtuous indignation at his oft-repeated falls, he signed a ‘Murphy pledge.’ Having learned the value of chloral for the horrors, now, in his abstinence from alcohol, he began the use of chloral. He would sit in the office and sleep in his chair, day after day. His speech became drawling and indistinct, and he could not remember what he read. At the end of two or three weeks he had an eruption appear on his face, neck, and shoulders, like acne. These pimples, at first hard and red, suppurated, being attended with much soreness and pain. “After being in this condition for some weeks he began to hear voices at night, rose from his bed in great terror, and ran to his father’s room, saying burglars were in the house, on several occasions. His neighbors were in a conspiracy against him; living in a double house, could hear them planning against him, through the walls. On going home at night would go at full run, waiting till very late, to have the streets deserted; asserted he was often pursued by a ‘band of niggers’ who had been hired to injure him. Heard people talking about him, whom he passed, even when I was with him and knew nothing was said. He continued in this state for several weeks; finally became exhausted, had to take to his bed, where he remained several weeks. He had been removed to his father’s farm, several miles distant, at this time, hence, not at this period under my observation. Now, being obliged to abstain, he got better; but when he got better, relapsed into his old habit. Now, he was sent to Fort Hamilton, and there kept for, I think, six months. Perhaps a record of this case can be found there. “He returned here, and has been fully restored. Though after his sojourn in Fort Hamilton he had another attack of his appetite for chloral, whiskey, etc., which lasted some months. “His doses of chloral, daily, would amount to half an ounce, I estimate, for days together. The data are impossible to learn, because he never kept it all in one bottle, and he had a supply located at various points, for convenience. “The eruption did not itch. It lasted during the time of taking the drug, and subsided after it was discontinued. There was also, at times, a use of valerian, in quantities unknown.” Dr. Roswell Park, of Chicago, Ill., writes me of a young man “who established the chloral habit after a series of business reverses. He was nervous and excitable. I have no idea as to what amount he took. He finally developed a suicidal tendency, jumped from a fourth-story window, sustained a compound comminuted fracture of the elbow, and other injuries, and finally died, about the tenth day, from acute mania and exhaustion.”