enfeebles the will, exacerbates the temper, produces a physical and nervous irritability which to an observer unacquainted with the cause seems irrational, unaccountable, extravagant, even frantic, but which afflicts the patient incomparably more than those, however near and however sensitive, on whom it is vented. Drugs, then, which enable the physician in most cases to check insomnia at an early stage—to secure, for example, in a case of chronic pain, six or seven hours of complete repose out of the twenty-four, to arrest a mischief which leads by the shortest and most painful route directly to insanity—are simply invaluable. It may seem a paradox, it is a truism, to say that in their value lies their peril. Because they have such power for good, because the suffering they relieve is in its lighter forms so common, because neuralgia and sleeplessness are ailments as familiar to the present generation as gout, rheumatism, catarrh to our grandfathers, therefore the medicines which immediately relieve sleeplessness and neuralgic pain are among the most dangerous possessions, the most subtle temptations, of civilized and especially of intellectual life. Every one of these drugs has, besides its immediate and beneficial effect, other and injurious tendencies. The relief which it gives is purchased at a certain price; and in every instance the relief is lessened or rendered uncertain, the mischievous influence is enhanced and aggravated by repetition; till, when the use has become habitual, it has become pure abuse, when the drug has become a necessity of life it has lost the greater part if not the whole of its value, and serves only to satisfy the need which itself alone has created. Contrary to popular tradition, we believe that of popular narcotics opium is on the whole, if the most seductive, the least injurious; chloral, which at first passed for being almost harmless, is probably the most noxious of all, having both chemical and vital effects which approach if they do not amount to blood-poisoning. It is said (we do not affirm with what truth) that the subsequent administration of half a teaspoonful of a common alkali operates as an antidote to some of these specific effects. The bromide of potash, another favorite, especially with women, is less, perhaps, a narcotic proper than a sedative. It is said not to produce sleep directly, like chloral or opium, by stupefaction, but at least in small doses simply to allay the nervous irritability which is often the sole cause of sleeplessness. But in larger quantities and in its ultimate effects it is scarcely less to be dreaded than chloral. It has been recommended as a potent, indeed a specific and the only specific, remedy for sea-sickness. But the state to which, as its advocate allows, the patient must be reduced, a state of complete nervous subjection to the power of the drug, seems worse than the disease, save in its most cruel and dangerous forms.