his or her best days, would have seemed impossible or unendurable. One woman thus restrained escaped in a _déshabille_ from her bed-room on a winter night of Arctic severity; ran for miles through the snow, and was fortunate enough to find a chemist who knew something of the fearful effect of such privation, and had the sense and courage to give in adequate quantity the poison that had now become the first necessary of life. In a word, narcotics, one and all, are, to those who have once fallen under their power, tyrants whose hold can hardly ever be shaken off, which punish rebellion with the rack, and with all those devices of torture which mediæval and ecclesiastical cruelty found even more terrible than the rack itself; while the most absolute submission is rewarded with sufferings only less unendurable than the punishment of revolt. De Quincey’s dreams under the influence of opium were to the tortures of resistance what the highest circle of purgatory may be to the lowest pit of the Inferno. But any reader who knows what nightmare is would think such tortures of the imagination, so vividly realized by a consciousness apparently intensified rather than impaired by slumber, a sufficient penalty for almost any human sin. Chloral, bromide of potash, chloroform, henbane, and their various combinations and substitutes are, however, by their very natures medicines and no more. They are taken in the first instance as such; at worst as medicinal equivalents for a quantity of alcohol which women are afraid to take or unable to obtain, much more commonly as medicines originally useful, mischievous only because the system has been accustomed to depend on and cannot dispense with them. Their effects at best are negatively, not actively, pleasurable. They relieve pain or insomnia, or the craving which they themselves have created; but their victims would, if they could, gladly be released from their tyranny. Their character, moreover, is if not immediately yet very rapidly perceptible. Very few can have used them for six months without becoming more or less alarmed by the consequences. The minority, for whom they are mere substitutes for alcohol, resort to them only when the system has already been poisoned, the habits incurably vitiated. With opium the case is different. In those which may be called its native countries, it is not a medicine but a stimulant or sedative, used for the most part in much greater moderation but in the same manner as wine or spirits among ourselves; as an indulgence pleasurable and innocent, if not actually desirable in itself. It suits the climates and temperaments to which the heating, exciting influence of alcohol is wholly unsuitable. It is, moreover, incompatible with the free use of the latter, a thing which may be said in some sense of most narcotics. Taken up by persons not yet addicted to intemperance, chloral and similar drugs operate to discourage the use, or at least