the free use, of wine or spirits by intensifying their effect to a serious and generally an unpleasant degree. But it does not appear that they act, like opium, to indispose the system for alcohol. To the opium-eater, as a rule, the exciting stimulus of alcohol, counteracting the quiet, dreamy influence of his favorite drug, is decidedly obnoxious; the action of chloral much more resembles that of the more stupefying and powerful spirits. A drunkard desirous to abandon his favorite vice, and reckless or incredulous of the possibility that the remedy may be worse than the disease, would probably find in opium the most powerful and effectual assistance and support to which he could have recourse. It has moreover a strong tendency to diminish the appetite for food, so much so that both in the East and in Europe severe privation tends to encourage and diffuse its use. Its peculiar danger, however, lies in the nature of the pleasure, and the remoteness of the pain and mischief which attend its use. Its effect on different constitutions and at different periods of life is exceedingly different. As De Quincey remarks, it is not essentially and primarily narcotic. It does not necessarily, immediately, or always produce sleep. Some fortunate temperaments reject it in all forms whatever. With these it produces immediate or speedy nausea, and consequent repugnance. But its most universal effect is the diffusion of comfort, quiet, calm, conscious repose, a general sensation of physical and mental ease throughout the system; not followed necessarily or generally by acute reaction, or even by depression. De Quincey’s earlier experience accords with that of most of those to whom opium is in some sense suited, to whom alone it is likely to become a dangerous temptation. Used once in a fortnight, or even once a week, it gives several hours of placid enjoyment, and if taken with some mild aperient and followed next morning by a cup of strong coffee, it generally gives a quiet night’s rest, entailing no further penalty than a certain not unpleasant lassitude on the morrow. A working-man, for instance, might take it every Saturday night for twenty years without other effect than a decided aversion to the public-house on Sunday, if he could but resist the temptation to take it oftener. Again, till it loses its power by constant use it is in many cases the surest and pleasantest of all anæsthetics; it relieves all neuralgic pains, tooth-ache and ear-ache for example, and puts, especially in combination with brandy, a quick and sure if by no means a wholesome check on the milder forms of diarrhœa.