The Portuguese, following the lead of Prince Henry, continued to look for the road to India by the Cape of Good Hope. The same end was sought by Christopher Columbus, following the suggestion of Toscanelli, and under-estimating the diameter of the globe, by sailing due west. The voyages of Columbus (1492-1498) resulted in the discovery of the West Indies and North America which barred the way to the Far East. In 1493 the pope, Alexander VI., issued a bull instituting the famous "line of demarcation" running from N. to S. 100 leagues W. of the Azores, to the west of which the Spaniards were authorized to explore and to the east of which the Portuguese received the monopoly of discovery. The direct line of Portuguese exploration resulted in the discovery of the Cape route to India by Vasco da Gama (1498), and in 1500 to the independent discovery of South America by Pedro Alvarez Cabral. The voyages of Columbus and of Vasco da Gama were so important that it is unnecessary to detail their results in this place. See COLUMBUS, CHRISTOPHER; GAMA, VASCO DA. Vasco da Gama. The three voyages of Vasco da Gama (who died on the scene of his labours, at Cochin, in 1524) revolutionized the commerce of the East. Until then the Venetians held the carrying trade of India, which was brought by the Persian Gulf and Red sea into Syria and Egypt, the Venetians receiving the products of the East at Alexandria and Beirut and distributing them over Europe. This commerce was a great source of wealth to Venice; but after the discovery of the new passage round the Cape, and the conquests of the Portuguese, the trade of the East passed into other hands. Spaniards in America.