Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measlesOpie, Eugene L. (Eugene Lindsay)
History
Epidemic Respiratory Disease: The pneumonias and other infections of the repiratory tract accompanying influenza and measles
Microscopic examination demonstrates the presence of acute bronchitis;
the lumina of the small bronchi contain polynuclear leucocytes and red
blood corpuscles. Accumulation of blood may separate the epithelium from
the basement membrane. The mucosa immediately below the epithelium
contains polynuclear leucocytes in fair abundance and the blood vessels
of the bronchial wall are much engorged. Respiratory bronchioles are
distended with polynuclear leucocytes and red blood corpuscles. In a
zone about each bronchiole, in areas corresponding to the small gray
spots seen upon the cut surface of the lung, the alveoli are filled with
polynuclear leucocytes. In the lung tissue intervening between these
spots of leucocytic pneumonia the alveoli are distended with red blood
corpuscles.
[Illustration:
Fig. 5.—Bronchopneumonia with hemorrhagic peribronchiolar
consolidation.
]
In favorable sections it is occasionally possible to follow the
bronchiole and alveolar duct, both filled with leucocytes, into an
infundibulum. The proximal part of the infundibulum contains polynuclear
leucocytes, whereas the distal part and its tributary alveoli are filled
with serum and red blood corpuscles.
When the lesion has persisted for a short time there is evidence of
beginning migration of polynuclear leucocytes from the blood vessels
into the alveoli which are filled with blood. The alveolar walls contain
numerous polynuclear leucocytes and leucocytes which have entered the
intraalveolar blood are numerous in contact with the wall but occur in
scant number in the center of the alveolar lumen.
Alveolar epithelium in contact with the blood in the lumen is usually
swollen and often uniformly nucleated.
The inflammatory process is evidently transmitted from the bronchioles
and to a less degree from the small bronchi to the adjacent alveoli.
Polynuclear leucocytes fill the lumen of the bronchiole and the alveoli
immediately adjacent; at the periphery of the focus of pneumonia, the
alveoli may contain fibrin. In such instances small bronchi (lined by a
continuous layer of columnar epithelial cells) may be surrounded by
alveoli containing fibrin.
In sections from one part of the lung, the alveoli between the
peribronchiolar foci of pneumonia may be uniformly filled with red blood
corpuscles, whereas in sections from another part pneumonic foci may be
surrounded by a zone of intraalveolar hemorrhage or of hemorrhage and
edema outside of which some air-containing tissue occurs. There are
transitions between this halo of intraalveolar hemorrhage and edema
surrounding each bronchiolar focus and complete hemorrhagic infiltration
of all intervening alveoli.
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