The expeditions of the German emperors to Italy, as well as the Crusades, offer numerous examples of how large armies may be destroyed by disease. So, for instance, in 963 or 964 the army of the Emperor Otto I was attacked by a severe pestilence in Italy—a murderous disease which was usually fatal in twenty-four hours. The German army of Henry IV in 1081–2, but especially after the capture of Rome on June 3, 1083, suffered from plagues in Italy; but the same army fared even worse in 1084, when a plague broke out and carried away, for example, the entire German garrison in Rome. In 1137 Lothair’s army was likewise attacked by infectious diseases in Italy. But by far the most devastating of all was the pestilence which broke out in Rome in August, 1167, shortly after the capture of the city by Frederick Barbarossa, and paved the way to a catastrophe which culminated in the complete annihilation of the German army. At that time many eminent men succumbed to the disease, the army dwindled away in the hands of the leaders, and the soldiers fled in vast numbers in order to escape certain death. Even after the Emperor Barbarossa’s withdrawal from Rome the pestilence continued to rage in his army, and it was a long time before it disappeared from the city. It was the true (bubonic) plague, and usually resulted fatally on the first day. In the winter of 1190–1 a pestilence broke out in Lower Italy in the army of Henry VI; it appeared at the beginning of the siege of Naples and carried away many eminent men. The king himself contracted the disease, and had to be taken to Capua.[5] The armies of the Crusades fared even worse; the mortality in the First Crusade, before and after the conquest of Antioch (1097–8), was terrible. The pestilence is said to have broken out first among the children and women who accompanied the armies, and its dissemination was favoured by a lack of sustenance and continual rainfall; from September to the 24th of November the pestilence carried away 100,000. The nature of the disease is not known, although it is known to have been very infectious. When a new army of 1,500 Germans arrived, it was quickly attacked by the disease and in a few days almost completely annihilated. Several hundred frequently died in a single day, and as the summer of 1099 was very hot and a number of bodies remained unburied, the pestilence lasted well into that year. In 1100 another pestilence raged among the crusaders. Again, during the Second Crusade a severe epidemic broke out in the army of the Emperor Louis VII at Attalia in Asia Minor; the pestilence spread rapidly among the inhabitants of the city, so that many houses, even entire streets, were depopulated.[6]