Well known in history is the great pestilence which in 1552 forced Emperor Charles V to raise the siege of Metz, which had been going on for two months (November and December). Maréchal gives us detailed information about this;[23] the Emperor’s army, he says, which consisted of 80,000 German, Spanish, and Italian troops, in addition to the enormous camp-following that always accompanied armies at that time, was reduced one-third by the end of December through desertion, disease, and disablement. According to the report of the Venetian physician, Andreas Gratiolo, the widespread diseases were typhus fever and dysentery. The appearance of these diseases was favoured by the congregating of such enormous numbers of people in tents and inadequate places of shelter, and also by the great dampness and the lack of the necessaries of life. The extreme cold, which prevented the dispersion and isolation of the patients, also favoured the dissemination of the disease. More than 200 men died in the barracks every day, while 10,000 men, all told, are said to have succumbed. It was also observed that the Spaniards and Italians suffered more than the _Landsknechte_ and other German troops, since they could not stand the severity of the climate so well. During the siege, hospital-fever and scurvy raged in the city itself, and after the siege was raised, in the night of January 1, 1553, typhus fever broke out there, having been borne into the hospitals by wounded soldiers from the enemy’s camp, or else brought back by citizens who had been out to inspect the position of the besiegers. During the siege the surrounding country had been most terribly ravaged by the enemy’s soldiers, so that the inhabitants were in the greatest misery, without food and without any source of help. For the spread of typhus fever this afforded a very favourable soil, and it raged furiously in the months of June and July in the villages surrounding Metz.