Epitome of the Pharmacopeia of the United States and the National Formulary: With CommentsHewlett, Albion Walter
Science
Epitome of the Pharmacopeia of the United States and the National Formulary: With Comments
Hewlett, Albion Walter
Medicine -- Formulae, receipts, prescriptions; Pharmacopoeias -- United States
=*Hydrargyri Chloridum Corrosivum (Hydrarg. Chlor. Corr.), Corrosive
Mercuric Chloride, U.S.P.= (Bichloride of Mercury, Corrosive Sublimate,
Mercuric Chloride, Perchloride of Mercury).--HgCl{2}.
Heavy, colorless crystals, crystalline masses or white powder,
odorless and with a characteristic metallic taste. Slowly soluble
in water (1:13.5) and freely soluble in alcohol (1:3.8). Its
solubility in water is increased by the addition of sodium or
ammonium chloride. Incompatible with soluble carbonates and
hydroxides, with iodides and with alkaloids and other organic
compounds. Reduced to calomel or metallic mercury by iron, zinc and
other reducing agents.
ACTION AND USES: Chiefly as a germicide and antiseptic;
also as a specific antisyphilitic agent. Acute mercuric
chloride poisoning is treated by raw eggs and lavage.
DOSAGE: 0.003 Gm. or 1/20 grain (U.S.P.) in solution
or pills. For hypodermic use in syphilis 0.01 Gm. or
1/6 grain daily (produces marked pain and irritation).
As antiseptic externally in solution from 1:20,000 to
1:2,000. As disinfectant of clothing, in 1:1,000 solution.
_Mulla Hydrargyri Chloridi Corrosivi (Mull. Hydrarg. Chlor. Corros.),
Corrosive Mercuric Chloride Mull, N.F._ (Unguentum Hydrargyri Chloridi
Corrosivi Extensum, N.F. III).--Corrosive mercuric chloride (0.2%),
alcohol, benzoinated suet and benzoinated lard.
_Toxitabellae Hydrargyri Chloridi Corrosivi (Toxitabel. Hydrarg. Chlor.
Corr.), Poison Tablets of Corrosive Mercuric Chloride, U.S.P._
(Corrosive Sublimate Tablets, Bichloride Tablets).--Tablets of an
angular shape colored blue, each having the word "Poison" and the skull
and cross bones design distinctly stamped on it. Each 1 Gm. tablet
contains about 0.5 Gm. or 8 grains corrosive mercuric chloride and 0.5
Gm. or 8 grains sodium chloride.
=*Hydrargyri Chloridum Mite (Hydrarg. Chlor. Mit.), Mild Mercurous
Chloride, U.S.P.= (Mercurous Chloride, Calomel, Protochloride of
Mercury, Subchloride of Mercury).--HgCl.
White or nearly white, odorless, tasteless powder. Insoluble in
water, alcohol or ether. Incompatible with alkalies, with oxidizing
acids like nitric acid, and with soluble bromides and iodides.
ACTION AND USES: A slow cathartic, fairly powerful and
relatively non-irritant. Should usually be followed by a
saline laxative. Should not be taken continuously as it
may salivate. Also employed as a diuretic in cardiac
dropsies. Intramuscular injections are very efficiently
antisyphilitic, but painful.
DOSAGE: Laxative, 0.15 Gm. or 2-1/2 grains (U.S.P.);
alterative, 0.015 Gm. or 1/4 grain (U.S.P.). From 0.005
to 0.02 Gm., or from 1/12 to 1/3 grain, may be given every
half hour or hour until from 0.1 to 0.2 Gm., or from 1-1/2 to
3 grains have been given. In the treatment of syphilis
0.1 Gm. or 1-1/2 grain in oily suspension is injected about
once a week.
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