Essays Upon Heredity and Kindred Biological Problems: Authorised TranslationWeismann, August
Science
Essays Upon Heredity and Kindred Biological Problems: Authorised Translation
Weismann, August
Evolution (Biology); Genetics; Reproduction
But it does not therefore follow that the somatic cells were compelled
to lose the power of unlimited cell-production, although in accordance
with the law of heredity, they could only give rise to cells which
resembled themselves, and belonged to the same differentiated
histological system. But as the fact of normal death seems to teach us
that they have lost even this power, the causes of the loss must be
sought outside the organism, that is to say, in the external conditions
of life; and we have already seen that death can be very well explained
as a secondarily acquired adaptation. The reproductive cells cannot
lose the capacity for unlimited reproduction, or the species to which
they belong would suffer extinction. But the somatic cells have lost
this power to a gradually increasing extent, so that at length they
became restricted to a fixed, though perhaps very large number of
cell-generations. This restriction, which implies the continual influx
of new individuals, has been explained above as a result of the
impossibility of entirely protecting the individual from accidents, and
from the deterioration which follows them. Normal death could not take
place among unicellular organisms, because the individual and the
reproductive cell are one and the same: on the other hand, normal death
is possible, and as we see, has made its appearance, among
multicellular organisms in which the somatic and reproductive cells are
distinct.
I have endeavoured to explain death as the result of restriction in the
powers of reproduction possessed by the somatic cells, and I have
suggested that such restriction may conceivably follow from a
limitation in the number of cell-generations possible for the cells of
each organ and tissue. I am unable to indicate the molecular and
chemical properties of the cell upon which the duration of its power of
reproduction depends: to ask this is to demand an explanation of the
nature of heredity—a problem the solution of which may still occupy
many generations of scientists. At present we can hardly venture to
propose any explanation of the real nature of heredity.
But the question must be answered as to whether the kind and degree of
reproductive power resides in the nature of the cell itself, or in any
way depends upon the quality of its nutriment.
Virchow, in his ‘Cellular Pathology,’ has remarked that the cells are
not only nourished, but that they actively supply themselves with food.
If therefore the internal condition of the cell decides whether it
shall accept or reject the nutriment which is offered, it becomes
conceivable that all cells may possess the power of refusing to absorb
nutriment, and therefore of ceasing to undergo further division.
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