The year 1844 was one of much trial and affliction. Her husband's only sister died of consumption on July 2nd; a grandson of much promise was taken off at the age of twelve by the same disease towards the end of July; in August and September her second son and two of his young daughters were rapidly carried off by malignant scarlet fever. In the spring of the following year the death of her brother-in-law, Sir Thomas Fowell Buxton, excited her tenderest feelings. In fact, there was a succession of bereavements, which caused her to say in her Journal, "Sorrow upon Sorrow!" and after writing the long list of deaths, she closes the entry with these words "O gracious Lord! bless and sanctify to us all this afflicting trial, and cause it to work for our everlasting good; and be very near to the widow and the fatherless; and may we all be drawn nearer to Thee, and Thy kingdom of rest and peace, where there will be no more sin, sickness, death, and sorrow." As to her own health, she rallied a little after returning home from Bath, but it was thought well to move from place to place for change of air, and for the pleasure of communion with loved friends. The beginning of 1845 saw her again in Norfolk, her husband and her daughter taking her to Earlham, where she enjoyed, for several weeks, the companionship of her brother, Joseph John Gurney, his wife, and other relatives. She went frequently to Meeting at Norwich, drawn in her wheeled chair, and thence ministering with wonderful life and power to those present. The Annual Meeting of the British Ladies Society, an excellent organisation for visiting and caring for female convicts, although usually held at Westminster, was this year held in the Friends' meeting-house at Plaistow. After the meeting, which she had addressed several times in a sitting posture, she invited those present to come to her home, and it was felt that her affectionate words at parting were probably the last they would hear from her in this world. As the year passed, it was thought that the air of the south coast might be useful, and the house at Ramsgate, Arklow House, which proved her last abode, was prepared for her. Her bed-chamber adjoined the drawing-room, with pleasant views of the sea, in which she delighted. While driving in the country, or being wheeled to the pier in a Bath-chair, she still strove to be useful, distributing Bibles and tracts, accompanied with a few words of kindly exhortation. Thus she was employed till the close of her days in work for the Master. She lingered, with gradual decay; and passed away, after a few days' illness which confined her to bed, on the morning of the 13th of October, 1845, in her 66th year. The last words she was heard to articulate, were "O dear Lord, help and keep Thy servant."