These figures testify to a nineteen-fold reduction in the number of
attacks of enteric fever, and to a threefold reduction in the number
of deaths from that disease, among the inoculated.... The only case
which occurred among the inoculated was that of a patient admitted to
hospital on the thirty-third day after inoculation. It would seem that
the disease was in this case contracted before anything in the nature
of protection had been established by the inoculation."
9. _Imperial Yeomanry Hospital, Pretoria._ Dr. Rolleston, Consulting
Physician to this hospital, writes in the _British Medical Journal_,
5th October 1901: "Among the _personnel_ of the hospital (17 medical
officers, 50 nursing sisters, 83 orderlies, etc.), total, 150, there
were 22 cases of enteric fever, or an incidence of 14.6 per cent. Of
the 150, 35 were inoculated, and of these, 6, or 17 per cent.,
suffered from enteric; while, of 115 non-inoculated members of the
_personnel_, 16, or 13.9 per cent., suffered from enteric fever; the
percentage is therefore higher among the inoculated. There were 2
deaths, both in non-inoculated patients. In 100 cases of enteric fever
among non-commissioned officers and men, taken mainly from
convalescent patients, only 8 had been previously inoculated; there
were 3 fatal cases, all among non-inoculated patients. Among 42
officers who had enteric, no fewer than 19 had been previously
inoculated; 6 of these 19 cases were severe in character, but none
were fatal; of the 23 non-inoculated cases, 7 were severe, and of
these 7, 3 ended fatally. The interval between inoculation and the
subsequent incidence of enteric fever varied between one and
twenty-one months, but in only four instances was the interval less
than six months. The average interval between inoculation and the
onset of enteric fever in these 19 cases was thirty-eight weeks.
"As far as these scanty figures go, they point to the conclusion (1)
that anti-typhoid inoculation does not absolutely protect against a
future attack of typhoid fever; (2) that when enteric occurs in an
inoculated person, there is, as a rule, an interval of about six
months; (3) that inoculation protects against a fatal termination to
the disease."
10. _Richmond Asylum, Dublin._ The _British Medical_ _Journal_, 26th
October 1901, contains a note by Professor Wright on an outbreak of
typhoid in this asylum during August to December 1900. Inoculations
were begun on 6th September, by Dr. Cullinan, and by 30th November 511
persons were inoculated. After careful criticism of all doubtful
cases, Professor Wright gives the following figures:--
_Comparative Incidence of Typhoid Fever in Inoculated and
Non-Inoculated, calculated upon the average strength of the
representative groups during the period intervening between the
commencement of the inoculations and the termination of the
epidemic._
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