At the age of fifteen Weir Mitchell entered the University of Pennsylvania. There he spent three years; and afterward he entered Jefferson Medical College, Philadelphia, in which his father was a professor. One of the severest disappointments in the son's life came in 1870, twenty years after graduation, when, notwithstanding the solicitation of influential friends, he failed of election to a professorship in Jefferson College. However, this disappointment, like the one which he met when he consulted Dr. Holmes about his first book of poems, worked eventually to his greater glory. After graduation from Jefferson College Dr. Mitchell, as we shall call our author henceforth, went to Paris, whence, owing to an attack of smallpox, he was obliged to return in less than two years. By this time the young doctor had lost sight of his literary star. His ambition was to teach medicine. The first article from his pen appeared in the _American Journal of Medical Science_. Other articles followed with quick regularity, but to none of these early writings, we believe, does Dr. Mitchell attach much importance. From 1858 until 1862, when he enlisted as an army surgeon, the doctor devoted his spare hours to the study of poisons, particularly snake poisons. Not long after the Civil War, by the way, one of the largest rattlesnakes ever sent to him died of cold. Dr. Mitchell had the skin preserved and tanned, and he sent it to Dr. Oliver Wendell Holmes with the suggestion that it might make a worthy binding for "Elsie Venner." "I thank you for it," Dr. Holmes wrote back, "especially because it makes an attractive binding, and I know that its bark is better than its bite." It would be interesting to pursue Dr. Mitchell's scientific achievements, but such a pursuit would be too long to agree with the purpose of this sketch. However, his career as a war surgeon is worth looking at, for it had something to do with his subsequent advent as a writer of fiction. Dr. Mitchell and his associates made a deep study not only of the effects of certain wounds but also of the effects of environment. Much of the curious information thus derived was given to the world through the medical papers. It was undoubtedly the study followed during this period which formed the base of Dr. Mitchell's now universally recognized success as a neurologist. The universality of his fame as a specialist in nervous diseases has two substantial witnesses. One is the oration delivered at Edinburgh University in 1895, when he received the title of Doctor of Laws. In that oration he was spoken of as "the chief ornament to medical science in the new world." The other witness is the story of his visit some years ago to Dr. Charcot, one of the great French authorities on nervous diseases. Dr. Mitchell did not give his name; he merely said that he was from Philadelphia, and that there was something the matter with his nerves.