(1) Sodium benzoate in small doses (under five-tenths of a gram per
day) mixed with the food is without deleterious or poisonous action
and is not injurious to health. (2) Sodium benzoate in large doses
(up to four grams per day) mixed with the food has not been found to
exert any deleterious effect on the general health, nor to act as a
poison in the general acceptance of the term. In some directions
there were slight modifications in certain physiological processes,
the exact significance of which modification is not known. (3) The
admixture of sodium benzoate with food in small or large doses has
not been found to injuriously affect or impair the quality or
nutritive value of such food.
Still later experiments under the auspices of the German government
(1913) showed that in the case of dogs and rabbits relatively large
doses of benzoic acid (corresponding to sixty to one hundred grams per
day for a man weighing one hundred and fifty pounds) were necessary in
order to produce demonstrable effects of any kind. This finding may be
considered to confirm in a general way the finding of the Referee Board
that four grams per day is harmless.
Probably the evidence respecting the effect of benzoic acids and the
benzoates when used as food preservatives constitutes as favorable a
case as can be made out at the present time for the employment of any
chemical substance. Benzoic acid is present in noteworthy amounts in
many fruits and berries, especially cranberries, and its presence in
these natural foods has never been connected with any injurious action.
In point of fact, substances present in many ordinary foodstuffs are
converted within the human body first into benzoic acid and then into
hippuric acid. Folin's masterly summing up is worth quoting:
Public-domain text, read in full here on John Shaqi.
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