Dr. Koch appears to have been questioned on his return to Europe by some journalists as to the results of his study of sleeping sickness during the past year and a half in Uganda. It was already known (three years ago), from the observations of Professor Minchin, Dr. Gray, and Dr. Tulloch (the Royal Society’s observers in Uganda), that the tsetse-fly in Uganda sucks the blood of crocodiles, also of fishes and of hippopotami. Dr. Koch confirms this observation. Minchin also observed a trypanosome in the blood of the crocodile differing from that of sleeping sickness. Whether crocodiles help, in an important degree, to keep tsetse-flies alive in the regions where they occur, by offering them a ready meal of blood, is uncertain. So far as the facts are known, they do not lead to the belief that the crocodile is a “reservoir host” for the trypanosome of sleeping sickness. “Reservoir-host” is a very useful and expressive name for animals which can tolerate or support a parasite in their blood which is deadly to other animals. The parasite flourishes in abundance in the reservoir-host with entire satisfaction to both host and guest. But a blood-sucking fly or gnat, of promiscuous tastes in the matter of blood, comes along, sucks the reservoir-host a bit, and then goes off for another meal to a susceptible animal, into which it introduces the parasite now adhering to its already blood-smeared proboscis or beak. Such a history was first established by Bruce in regard to the trypanosome parasite which causes the deadly nagana disease in the “fly-belts” of South Africa. The big game animals are reservoir-hosts to this parasite, from which they are carried by the tsetse-fly to horses, mules, and dogs, which, being of foreign origin, are not tolerant of it, but are killed by the poison to which its multiplication in their blood gives rise. Thus, too, native children, both in Africa and the East Indies, appear to be tolerant of the malaria parasite, and act as reservoir-hosts from which the spot-winged gnats suck and distribute the parasite to the non-tolerant, susceptible adult natives and white men.