In 1833--the time of the great cholera epidemic in this country--she was left by herself, in a house where all its occupants had fled through fear. Trusting in the God of Israel for protection, she experienced the full force of those sublime words of King David: "He that dwelleth in the secret place of the Most High shall abide under the shadow of the Almighty. He shall cover thee with His feathers, and under His wings shalt thou trust. Thou shalt not be afraid for the terror by night, nor for the arrow that flieth by day; nor for the pestilence that walketh in darkness; nor for the destruction that wasteth at noon-day." On arriving in New York, she immediately connected herself in church fellowship with the Canal Street Presbyterian Church, under the ministry of the Rev. Dr. McCarthy, and became a Sabbath-school teacher. Some of the first impressions made on her mind by her pastor were continually repeated, even up to the hour of her death. In one address, delivered to young people, he begged them not to allow Satan to get even his little finger in, for he generally commenced with little sins, and by and by he would get his two fingers in, and then his whole hand, and twist you around as he chose, instead of allowing you to obey the commands of God. Shortly after she landed in this country she was invited by an acquaintance to go to Brooklyn, to church. She consented, and attended the service; but, on her return, while stepping off the ferry-boat, she slipped, and fell into the river, and narrowly escaped drowning. She resolved, by God's grace, that she would never put her foot on a ferry-boat on the Sabbath again, while she lived, which vow she kept to the close of her life. It was her usual custom on the street, if she heard any person using profane language, to reprove them, by saying, "Don't dare take the name of my Saviour in vain." In the year 1839 she was married to Elder James Knowles, by the Rev. Dr. McLeod, of the First Reformed Presbyterian Church, Prince's Street. At this time she joined the above church, that she might be in full fellowship at the same communion-table with her husband. In her earnest endeavors to faithfully serve her Lord and Master, she was sorely tried by a woman who lived in the same house with her. And herein do we see the goodness of God, in imparting grace to her to strenuously resist temptation. This woman did all in her power to lead her astray by offering her strong drink. She would visit her frequently after her husband had gone to his business, and bring the bottle and glass. She determined to change her place of residence, and before her husband returned home, she had engaged new apartments, and had her furniture all removed. Even after her removal, the woman followed her up, and became a tenant in the same house, and the same temptations were renewed. She once more got up and moved out of the house, never once yielding to the woman's persistent temptation.