From this mode of origin of external cicatrices, it is easy to conceive, 1st. why they adhere intimately to the places in which they are found, and have no laxity in the integuments; 2d. why the skin approximates from all the neighbouring parts to cover the wound; 3d. why it wrinkles in approximating; 4th. why, where it yields the most, the cicatrix is the smallest, as in the scrotum, the axilla, &c.; and why on the contrary it is the largest, where it yields but little, as on the sternum, the cranium, the great trochanter, &c.; 5th. why the thickness of all cicatrices is uniformly in an inverse ratio to their width; in fact as there is only the same quantity of cellular granulations to form them, it is necessary that they should lose in one way what they gain in another; hence those that are broad are much more easily torn; 6th. why they have not a regular organization, do not partake of the functions of the cutaneous organ they replace, and why their texture is absolutely different from this organ. The cicatrization of wounds left to themselves, especially those with loss of substance, differs essentially from the union by the first intention, which is effected by the agglutination of the edges. In this last there is neither the second period, that of fleshy granulations, nor the third, that of suppuration, nor the fourth, that of sinking down. Union succeeds immediately to the first, that of inflammation. We see, from all that has been said, that the cellular texture is the essential agent in the production of all cicatrices, that it forms their basis and their principle, that without it they could not take place, and that they depend especially upon the property it has of extending and increasing. _Influence of the cellular texture in the formation of tumours._