have an influence especially upon the internal life, and which affect the organs of it more particularly than those of external life; 6th. long-continued efforts of the mind, which in a particular manner affect the brain, consequently the first effect is upon animal life, though I have observed that an injury of the functions of this life has less effect upon corpulency than that of the functions of the other; 7th. all evacuations unnaturally increased, as those of the bile, the urine, the saliva, &c.; too frequent emissions of semen, &c. catarrhs, those especially that are seated on large surfaces, as the pulmonary, intestinal, &c.; 8th. long heat of summer, compared with the cold of winter, which is in general favourable to an increase of fat; 9th. running, hard labour, fatigue of every kind; 10th. long diseases, those especially where it is necessary to use only weak aliments, and not being able to continue even these for a long time; 11th. long-continued watchfulness; long sleep producing a contrary effect, that of increasing the fat; 12th. the immoderate use of spirituous liquors, &c. &c.; 13th. the use of acrid and spicy aliments, of those which have opposite properties to the farinaceous, &c. &c. I do not cite a great number of the causes of emaciation; after these it will be easily perceived what are omitted. I would only remark, that almost all may be referred to two principles, viz. 1st. a general weakness of the powers, a weakness that acts upon the cellular system, as upon all the others, and produces there this phenomenon; 2d. a partial weakness of this system, a weakness arising from the affection of some other organ, whose action seems to increase at the expense of that of the cellular texture. _Different states of the fat._ The fat is almost always solid and coagulated in dead bodies, but in the living it approaches nearer a liquid state, at least in certain parts, as around the heart, the great vessels, &c. Under the skin it has uniformly more consistence. In many experiments, where I have had occasion to open living animals with red and warm blood, I have never found it exactly flowing as it is when it is melted, though many authors have pretended that it is so, an opinion founded upon the belief that the vital heat would keep it melted. Undoubtedly a degree of heat equal to that of our bodies, acting upon fat out of the body, would make it much more fluid than it is in the living subject. Besides, we know that the temperature is nearly uniform, and that the degrees of the consistence of fat vary remarkably. There is a great difference between that of the omentum, which is among the most fluid of the economy, and that of the neighbourhood of the kidnies, the skin, which is much firmer. Many animals with red and cold blood have liquid fat.