Philadelphia. Only a few years ago the literature of glaucoma was big with discussions of the comparative value of the surgical and non-surgical treatment of glaucoma, and especially of the chronic types of this disease. Now, thanks to the achievements of Lagrange, Fergus, Herbert and Elliot, the value of a filtering cicatrix, although known for a long time, has attained increased importance, due to the improvement and elaboration of operative technic, and the medical journals of the day are weighted with opinions and experiences from all over the world as to these surgical measures. But true as this is, we are not yet in a position to discard non-surgical procedures (1) because operation is not always possible, (2) because operation is not always permitted, and (3) because in certain circumstances operation is not advisable. Hence a glance at the non-surgical methods of reducing increased intra-ocular tension is not out of place, and for convenience they may be catalogued as follows: 1. Myosis produced by means of solutions of various drugs, a myosis followed by reduction of intra-ocular tension. 2. Reduction of tension by means of various mechanical measures, notably massage, vibration massage and suction massage, and by means of electricity and diathermy. 3. Indirect reduction of intra-ocular tension, accomplished by lowering general vascular pressure. 4. Reduction of ocular tension by stimulation of osmosis, of lymphagog activity, of absorption of edema, and of capillary contractility, and by decreasing affinity of ocular colloids for water. 1. _The Myotics._ Of these, eserin (physostigmin) and pilocarpin, with their respective salts, the sulphate and the salicylate in the first instance, and the hydrochlorid and the nitrate in the second, are well established in favor and efficiency. Personally, it has always seemed to me that the salicylate of eserin is preferable to the sulphate, but I have not persuaded myself that the nitrate of pilocarpin possesses material advantages over the hydrochlorid, although some authors prefer it. With arecalin, the alkaloid of the Betel nut, I have no experience, nor have I used its mixture with eserin, recommended by Merck as more potent than either of the drugs in separate solution. The substance isophysostigmin, found with eserin in Calabar bean, according to Ogiu, exceeds in its myotic activity the sulphate of eserin, _i. e._, 1/80 of a grain of the drug is equal to 1/60 of a grain of the sulphate of eserin, but it is certainly not less irritating than physostigmin, and according to Stephenson's researches, is more so, and in this sense has no superiority over the usual alkaloid. In general terms, it may be said that the time has not arrived to make a preachment "on the passing of eserin and pilocarpin."