3. _Indirect reduction of increased intra-ocular tension brought about by lowering general vascular pressure._ Much has been written in regard to the association between increased vascular pressure and increased intra-ocular pressure. It is not my province to analyze observations often contradictory and not infrequently inaccurate. This much seems to be established: First, that at corresponding ages there is usually a higher average blood pressure in glaucomatous subjects than there is in non-glaucomatous subjects; second, that arteriosclerosis and therefore usually increased blood pressure, with all its concomitant conditions, is correctly classified as an exciting cause of glaucoma; and third, that the regulation of this increased blood pressure is part of the advantageous management of increased intra-ocular pressure, although it may be too much to say, as Gilbert has, that blood pressure and intra-ocular pressure rise and fall together. It may be true, as Thomas Henderson says, that the intra-ocular pressure is influenced by changes in the general arterial or general venous pressures, whereby a rise in general arterial pressure induces a proportionate rise in the intra-ocular pressure, but it would seem that future investigations must confirm this statement before it can be entirely accepted, as well as his further statement that the effect of an increased general venous pressure is a direct one, producing millimeter for millimeter a corresponding increase in the intra-ocular pressure. Now, it goes without saying, if these data are correct, or even only partly correct, that part of the treatment of the increased intra-ocular pressure state must be constitutional in that the vascular pressures should be lowered in order that the beneficial effect of their relationship to the intra-ocular pressure shall be established. It is further a great mistake to drive down a high arterial pressure simply because that exists. In other words, it is often necessary from the general standpoint that a certain amount of plus pressure shall remain if the patient's general well-being is to be maintained. There must always be a differential diagnosis between plus pressure and what may be called over plus pressure. That is to say, a man may be perfectly comfortable and properly need, for example, a pressure of 160 or 165 mm., which is above the physiologic limit, but which is a plus pressure, while some disturbance in his general life may add to that 10, 15 or 20 mm. more of pressure, which is then the over plus amount. This over plus amount may be in association with a rise of intra-ocular pressure, and must be eliminated if the latter is to be controlled by a non-operative procedure, or, indeed, by an operative one.