As you will remember, the strength of ordinary crystallized sodium citrate in water should be from 4.05 to 5.41 per cent. Of this five to fifteen minims are injected, the eye having been previously cocainized and adrenalinized. With frequent injections the weaker of the two solutions is mixed with 2 to 4 parts of physiologic salt solution. These authors in no sense claim to cure glaucoma, but to ameloriate it and reduce the tension. Weekers has used the salts of calcium, 3 grams a day, with success in so far as lowering of tension is concerned, although it must be stated, as a reviewer of his work has said, that his recommendation of this drug in these respects is poorly supported. On the other hand, Tristiano seems to have proved that calcium chlorid is capable of lowering ocular tension and clinically may be used as an adjuvant in the treatment of glaucoma for this purpose, largely because he believes that he has proven that it facilitates the absorption of edema. Darier has reported that a single subconjunctival injection of a milligram of iodate of sodium has cleared the cornea and lessened the intra-ocular pain in glaucoma. What shall be said in regard to certain medicinal agents which stimulate the lymphagogue activity of the eyeball in their relation to the reduction of intra-ocular tension, notably of dionin? Toczyski's experiments with this drug on the normal eye indicate that it produces first a rise of tension, which shortly falls to the normal and sometimes below it, the tension being high as long as the primary narrowing of the pupil is maintained, but more than one author, particularly A. Senn, holds an opposite view and reports acute glaucoma following its instillation into a chronic glaucomatous eye. He believes that dionin not only does not reduce the tension but hinders the filtration through the anterior lymph channels by the pressure of the edema which is produced on the veins and by the increased secretion of the ciliary processes. In spite of this statement, most of us must agree with Karl Grossman's observations that certainly in acute and particularly in chronic secondary glaucoma, this is a most valuable agent, especially if it is combined with holocain, which Paul Knapp in his well-known research has proved can reduce the tension even of the normal eye. I cannot think that anybody who has systematically used dionin with holocain, the former in gradually increasing strength, beginning with 2 per cent and going up to 8 per cent, in various types of acute glaucoma, particularly of the secondary variety, can fail to have noted a favorable influence.